What are you picking here? I think tools of the trade is great later when you already have discard synergy but not as a neow pick. Adrenaline is all around great and
Tradeskills Alchemy - Project Lazarus Wiki
Age of Alchemy — Google Arts & Culture
A Guide to Alchemy | Wiki | Epic Fantasy Amino
Tools of the Trade: Maximizing the value of the alchemy tool - The Lazy Goldmaker